But a 22-year-old woman has trumped them all - by growing a full-sized extra nipple on the sole of her foot.
Although one in 50 women and one in 100 men have extra nipples, according to the California-based Dermatology Journal it's the first time one has ever been discovered so far down somebody's body.
The woman told doctors she had had the unusual growth - which is almost two inches wide - all her life, and it had never caused her any pain.
Between one and five per cent of the population have the condition, known as supernumerary breast tissue.
Although most of the time extra nipples are found along the milk lines, which run from the genitals to the armpits, they have been discovered on the back, thigh or even the face - but never the feet.
Mark Wahlberg has a third nipple just below his left one. The former Calvin Klein model considered having it removed but then changed his mind, calling it his most 'prized possession'.
Last week dermatologist Dr Katherine Rothman said she believed Zac Efron had not one but two extra nipples, below his normal ones on his chest.
His spokesman denied the claims, but it prompted new interest in the topic - and the rediscovery of the 22-year-old woman's case, which was first published in Dermatology Journal in 2006.
According to researchers in Brazil: 'A 22-year-old woman sought medical care for a lesion in the plantar region of her left foot, a well-formed nipple surrounded by areola and hair.
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